Post-doctoral fellow in Translational Nanomedicine and Brain Cancer, Greineder/Lahann/Castro laboratories, University of Michigan

We are looking for candidates with experience in nanotechnology, pharmacokinetics, and/or cancer biology who are interested in joining a multi-disciplinary, collaborative team developing novel, translational therapies for glioblastoma multiforme (GBM).

We recently reported long-term survival benefit in intracranial GBM-bearing mice treated with synthetic protein nanoparticles (SPNPs) loaded with a targeting peptide and siRNA against STAT3. Our group (Greineder, Lahann, Castro/Lowenstein laboratories) has now been funded by NINDS to define the mechanism of tumor accumulation, mode of therapeutic action, and therapeutic efficacy of this nanomedicine in combination with standard of care radiation and chemotherapy. We also continue to develop improved SPNP formulations in preparation for eventual commercialization and clinical testing.

For this position, we are particularly interested in candidates with practical skills in one or more of the following areas: nanoparticle formulation, protein radiochemistry, HPLC, flow cytometry, confocal microscopy, and/or in vivo models of cancer. While applicants with prior experience working with rodent models will be prioritized, those without experience but highly motivated to gain these skills will also be considered.

The research fellow will have the unique opportunity to innovate, learn a wide range of state-of-the-art skills across several laboratories, and to work on a therapeutic with real potential for future commercialization and clinical testing.

Required skills: Ph.D. in an appropriate discipline (Pharmacology, Biomedical or Chemical Engineering, Cancer Biology, Biochemistry, etc). We are looking for someone with strong work ethic, good communication skills, and willingness to work on a multi-disciplinary and international investigative team. A desire to learn about translational therapeutics and to mentor graduate students is mandatory.

Start date: as soon as possible.

Application procedure: Please e-mail cover letter, CV, and references with available start date to coling@med.umich.edu, lahann@umich.edu, or mariacas@med.umich.edu.

The Greineder laboratory is actively recruiting graduate students for work on a number of projects:

• Therapeutic nanoparticles for glioblastoma

• Biotherapeutics for IgG-mediated hemolysis

• Drug-delivery to and across the blood-brain barrier (BBB)

• Targeted, stimuli responsive therapies for bone disorders

Prospective PhD or masters students should look for Dr. Greineder in the upcoming PIBS Match-a-thon (June 1st) or directly e-mail @ coling@med.umich.edu.